منابع مشابه
Aerobic metabolism of pyrazine compounds by a Pseudomonas species.
The action of purified mushroom tyrosinase (Koch-Light Laboratories, Colnbrook, Bucks., U.K.) on dopa and 6-hydroxydopa (Sigma Chemical Co., St. Louis, MO, U.S.A.) was followed spectrophotometrically by using the assay method of Pomerantz & Murthy (1974). The assay mixture consisted of substrate (3pmol) and enzyme (0.05pg) in phosphate buffer (50mM, pH6; 3ml); the blank cuvette contained all th...
متن کاملStudies on pyrazine derivatives. XLVII. Synthesis and antibacterial activity of novel pyrazine derivatives with amidoxime moiety.
The new pyrazine derivatives exhibiting an antibacterial activity have been synthesized. Initial amidoxime 1 was obtained in the reaction of pyrazinecarbonitrile with hydroxylamine. Upon treatment of amidoxime with methyl iodide O-methyl derivative 2 was formed. Both amidoximes were transformed into imidoyl chlorides 3, 4. Then the chloride atom in those derivatives was substituted with various...
متن کاملMolecular mechanics (MM3) calculations on lithium amide compounds
The MM3 force field has been extended to deal with the lithium amide molecules that are widely used as efficient catalysts for stereoselective asymmetric synthesis. The MM3 force field parameters have been determined on the basis of the ab initio MP2/6-31G* and/or DFT (B3LYP/6-31G*, B3-PW91/6-31G*) geometry optimization calculations. To evaluate the electronic interactions specific to the lithi...
متن کاملFullerenes as the carriers of compounds with amide bond.
Fullerenes are molecules created solely of carbon and have a highly unusual attributes. The smallest structure in the fullerene family is conformation C20, which consists of pentagonal rings only, resulting in its instability. The C60 is the first fullerene containing 12 pentagonal and 20 hexagonal rings in which pentagons do not share an edge. It results in good stability of the carbon cage. T...
متن کاملSynthesis and characterization of novel iminobenzoates with terminal pyrazine moieties
Apart from its numerous biological activities like antidiabetic, anti-inflammatory, antimicrobial, pyrazine moiety plays an important role in luminescent materials. Its role in luminescent materials is due to its highly electron deficient nature specially when it is in the centre along the mainstay of extended π-conjugated systems. Similarly, new liquid crystalline compounds are being made cons...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2015
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.5b00186